Evaluation of pulse wave velocity for predicting major adverse cardiovascular events in post-infarcted patients; comparison of oscillometric and MRI methods

Evaluation of pulse wave velocity for predicting major adverse cardiovascular events in post-infarcted patients; comparison of oscillometric and MRI methods Zsofia Meiszterics1, Tamas Simor1, Rob J. van der Geest2, Nelli Farkas3, Balazs Gaszner1,* Show Less 1 Heart Institute, Medical School, University of Pecs, 7624 Pecs, Hungary 2 Radiology Department, Leiden University Medical Center, 2333 ZA Leiden, Netherlands 3 Institute of Bioanalysis, Medical School, University of Pecs, 7624 Pecs, Hungary *Correspondence: gaszner.balazs@pte.hu (Balazs Gaszner) Academic Editor: Hack-Lyoung Kim Rev. Cardiovasc. Med. 2021, 22(4), 1701–1710; https://doi.org/10.31083/j.rcm2204178 Submitted: 3 September 2021 | Revised: 29 October 2021 | Accepted: 11 November 2021 | Published: 22 December 2021 (This article belongs to the Special Issue Arterial Stiffness in Cardiovascular Disease) Copyright: © 2021 The Author(s). Published by IMR Press. This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Download PDF Brower Figures Cite Abstract Increased aortic pulse wave velocity (PWV) has been proved as a strong predictor of major adverse cardiovascular events (MACE) in patients after myocardial infarction (MI). Due to the various technical approaches the level of high PWV values show significant differences. We evaluated the cut-off PWV values for MACE prediction using cardiac magnetic resonance imaging (CMR) and oscillometric methods for validating the prognostic value of high PWV in post-infarcted patients. Phase contrast imaging (PCI) and oscillometric based Arteriograph (AG) were compared in this 6 years follow-up study, including 75 consecutive patients of whom 49 suffered previous ST-elevation myocardial infarction (STEMI). Patients received follow-up for MACE comprising all-cause death, non-fatal MI, ischemic stroke, hospitalization for heart failure and coronary revascularization. An acceptable agreement and significant correlation (rho: 0.332, p < 0.01) was found between AG and CMR derived PWV values. The absolute values, however, were significantly higher for AG (median (IQR) : 10.4 (9.2–11.9) vs 6.44 (5.64–7.5) m/s; p < 0.001). Totally 51 MACE events occurred during the 6 years follow-up period in post-infarcted patients. Kaplan-Meier analysis in both methods showed significantly lower event-free survival in case of high PWV (CMR: